A double-strand break within a yeast artificial chromosome (YAC) containing human DNA can result in YAC loss, deletion or cell lethality.

Human chromosomal DNA contains many repeats which might provide opportunities for DNA repair. We have examined the consequences of a single double-strand break (DSB) within a 360-kb dispensable yeast artificial chromosome (YAC) containing human DNA (YAC12). An Alu-URA3-YZ sequence was targeted to se...

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書目詳細資料

發表在:	Mol Cell Biol
Principais autores:	Bennett, C B, Westmoreland, T J, Snipe, J R, Resnick, M A
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 1996
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231440/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8754842/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.8.4414
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