Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.

The human interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. These receptors belong to the cytokine recept...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Stomski, F C, Sun, Q, Bagley, C J, Woodcock, J, Goodall, G, Andrews, R K, Berndt, M C, Lopez, A F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231298/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8649415/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.6.3035
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