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Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.

The human interleukin-3 receptor (IL-3R) is a heterodimer that comprises an IL-3 specific alpha chain (IL-3R alpha) and a common beta chain (beta C) that is shared with the receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-5. These receptors belong to the cytokine recept...

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Библиографические подробности
Главные авторы: Stomski, F C, Sun, Q, Bagley, C J, Woodcock, J, Goodall, G, Andrews, R K, Berndt, M C, Lopez, A F
Формат: Artigo
Язык:Inglês
Опубликовано: 1996
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC231298/
https://ncbi.nlm.nih.gov/pubmed/8649415
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