An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.

We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences. It binds specifically to regulatory sequences in the promot...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Filippova, G N, Fagerlie, S, Klenova, E M, Myers, C, Dehner, Y, Goodwin, G, Neiman, P E, Collins, S J, Lobanenkov, V V
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231272/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8649389/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.6.2802
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