An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.

We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences. It binds specifically to regulatory sequences in the promot...

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Hauptverfasser: Filippova, G N, Fagerlie, S, Klenova, E M, Myers, C, Dehner, Y, Goodwin, G, Neiman, P E, Collins, S J, Lobanenkov, V V
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC231272/
https://ncbi.nlm.nih.gov/pubmed/8649389
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