A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction.

GATA-1, a transcription factor essential for the development of the erythroid lineage, contains two adjacent highly conserved zinc finger motifs. The carboxy-terminal finger is necessary and sufficient for specific binding to the consensus GATA recognition sequence: mutant proteins containing only t...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Trainor, C D, Omichinski, J G, Vandergon, T L, Gronenborn, A M, Clore, G M, Felsenfeld, G
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231211/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2238
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