A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction.

GATA-1, a transcription factor essential for the development of the erythroid lineage, contains two adjacent highly conserved zinc finger motifs. The carboxy-terminal finger is necessary and sufficient for specific binding to the consensus GATA recognition sequence: mutant proteins containing only t...

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Bibliographic Details
Main Authors: Trainor, C D, Omichinski, J G, Vandergon, T L, Gronenborn, A M, Clore, G M, Felsenfeld, G
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC231211/
https://ncbi.nlm.nih.gov/pubmed/8628290
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