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Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB.

In resting T lymphocytes, the transcription factor NF-kappaB is sequestered in the cytoplasm via interactions with members of the I kappa B family of inhibitors, including IkappaBalpha and IkappaBbeta. During normal T-cell activation, IkappaBalpha is rapidly phosphorylated, ubiquitinated, and degrad...

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Udgivet i:Mol Cell Biol
Principais autores: McKinsey, T A, Brockman, J A, Scherer, D C, Al-Murrani, S W, Green, P L, Ballard, D W
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231195/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628274/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.5.2083
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