Cysteine Mutagenesis and Computer Modeling of the S6 Region of an Intermediate Conductance IKCa Channel

Cysteine-scanning mutagenesis (SCAM) and computer-based modeling were used to investigate key structural features of the S6 transmembrane segment of the calcium-activated K(+) channel of intermediate conductance IKCa. Our SCAM results show that the interaction of [2-(trimethylammonium)ethyl] methane...

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Bibliografiske detaljer
Main Authors: Simoes, Manuel, Garneau, Line, Klein, Hélène, Banderali, Umberto, Hobeila, Fadi, Roux, Benoit, Parent, Lucie, Sauvé, Rémy
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311397/
https://ncbi.nlm.nih.gov/pubmed/12084779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028586
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