Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

Proteins with intrinsically disordered domains are implicated in a vast range of biological processes, especially in cell signaling and regulation. Having solved the quaternary structure of the folded domains in the tumor suppressor p53 by a multidisciplinary approach, we have now determined the ave...

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Main Authors: Wells, Mark, Tidow, Henning, Rutherford, Trevor J., Markwick, Phineus, Jensen, Malene Ringkjobing, Mylonas, Efstratios, Svergun, Dmitri I., Blackledge, Martin, Fersht, Alan R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2311362/
https://ncbi.nlm.nih.gov/pubmed/18391200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801353105
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