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Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.

Extracellular stimuli that activate the transcription factor NF-kappaB cause rapid phosphorylation of the IkappaBalpha inhibitor, which retains NF-kappaB in the cytoplasm of nonstimulated cells. Phosphorylation of IkappaBalpha is followed by its rapid degradation, the inhibition of which prevents NF...

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Udgivet i:Mol Cell Biol
Principais autores: DiDonato, J, Mercurio, F, Rosette, C, Wu-Li, J, Suyang, H, Ghosh, S, Karin, M
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8657102/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.4.1295
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