Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.

p16CDKN2 specifically binds to and inhibits the cyclin-dependent kinases CDK4 and CDK6, which function as regulators of cell cycle progression in G1 by contributing to the phosphorylation of the retinoblastoma protein (pRB). Human cell lines lacking functional pRB contain high levels of p16 RNA and...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Hara, E, Smith, R, Parry, D, Tahara, H, Stone, S, Peters, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8622687/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.3.859
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!