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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.

p16CDKN2 specifically binds to and inhibits the cyclin-dependent kinases CDK4 and CDK6, which function as regulators of cell cycle progression in G1 by contributing to the phosphorylation of the retinoblastoma protein (pRB). Human cell lines lacking functional pRB contain high levels of p16 RNA and...

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Udgivet i:Mol Cell Biol
Principais autores: Hara, E, Smith, R, Parry, D, Tahara, H, Stone, S, Peters, G
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231066/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8622687/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.3.859
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