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Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation

Brief periods of cardiac ischemia trigger protection from subsequent prolonged ischemia (preconditioning). ɛ Protein kinase C (ɛPKC) has been suggested to mediate preconditioning. Here, we describe an ɛPKC-selective agonist octapeptide, ψɛ receptor for activated C-kinase (ψɛRACK), derived from an ɛP...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Dorn, Gerald W., Souroujon, Miriam C., Liron, Tamar, Chen, Che-Hong, Gray, Mary O., Zhou, Hui Zhong, Csukai, Michael, Wu, Guangyu, Lorenz, John N., Mochly-Rosen, Daria
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23103/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10536002/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12798
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