Sustained in vivo cardiac protection by a rationally designed peptide that causes ɛ protein kinase C translocation

Brief periods of cardiac ischemia trigger protection from subsequent prolonged ischemia (preconditioning). ɛ Protein kinase C (ɛPKC) has been suggested to mediate preconditioning. Here, we describe an ɛPKC-selective agonist octapeptide, ψɛ receptor for activated C-kinase (ψɛRACK), derived from an ɛP...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Dorn, Gerald W., Souroujon, Miriam C., Liron, Tamar, Chen, Che-Hong, Gray, Mary O., Zhou, Hui Zhong, Csukai, Michael, Wu, Guangyu, Lorenz, John N., Mochly-Rosen, Daria
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23103/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10536002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.22.12798
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