Abrogation of the alternative complement pathway by targeted deletion of murine factor B

To investigate the role of complement protein factor B (Bf) and alternative pathway activity in vivo, and to test the hypothesized potential genetic lethal effect of Bf deficiency, the murine Bf gene was interrupted by exchange of exon 3 through exon 7 (including the factor D cleaving site) with the...

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Main Authors: Matsumoto, Mitsuru, Fukuda, Wataru, Circolo, Antonella, Goellner, Joseph, Strauss-Schoenberger, Jena, Wang, Xuefeng, Fujita, Shigeru, Hidvegi, Tunde, Chaplin, David D., Colten, Harvey R.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23097/
https://ncbi.nlm.nih.gov/pubmed/9238044
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