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mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation.

Poly(A) tail removal is a critical first step in the decay pathway for many yeast and mammalian mRNAs. Poly(A) shortening rates can be regulated by cis-acting sequences within the transcribed portion of mRNA, which in turn control mRNA turnover rates. The AU-rich element (ARE), found in the 3' untra...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Principais autores: Chen, C Y, Xu, N, Shyu, A B
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230830/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7565731/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.10.5777
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