Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions.

SH3 domains mediate intracellular protein-protein interactions through the recognition of proline-rich sequence motifs on cellular proteins. Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two...

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Bibliografiske detaljer
Main Authors: Weng, Z, Rickles, R J, Feng, S, Richard, S, Shaw, A S, Schreiber, S L, Brugge, J S
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC230813/
https://ncbi.nlm.nih.gov/pubmed/7565714
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