A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer.

The cardiac troponin T pre-mRNA contains an exonic splicing enhancer that is required for inclusion of the alternative exon 5. Here we show that enhancer activity is exquisitely sensitive to changes in the sequence of a 9-nucleotide motif (GAGGAAGAA) even when its purine content is preserved. A seri...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Ramchatesingh, J, Zahler, A M, Neugebauer, K M, Roth, M B, Cooper, T A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230736/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7651409/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.9.4898
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