Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.

Normal cells have a strictly limited growth potential and senesce after a defined number of population doublings (PDs). In contrast, tumor cells often exhibit an apparently unlimited proliferative potential and are termed immortalized. Although spontaneous immortalization of normal human cells in vi...

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Main Authors: Rogan, E M, Bryan, T M, Hukku, B, Maclean, K, Chang, A C, Moy, E L, Englezou, A, Warneford, S G, Dalla-Pozza, L, Reddel, R R
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC230718/
https://ncbi.nlm.nih.gov/pubmed/7651392
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