Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

Ítems similars

• The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.
  per: Knoepfler, P S, et al.
  Publicat: (1995)
• Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.
  per: Knoepfler, P S, et al.
  Publicat: (1996)
• Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex.
  per: Lu, Q, et al.
  Publicat: (1996)
• The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis.
  per: Chang, C P, et al.
  Publicat: (1997)
• Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif.
  per: Phelan, M L, et al.
  Publicat: (1995)