Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

E2A-PBX1 is the oncogene produced at the t(1;19) chromosomal breakpoint of pediatric pre-B-cell leukemia. Expression of E2A-Pbx1 induces fibroblast transformation and myeloid and T-cell leukemia in mice and arrests differentiation of granulocyte macrophage colony-stimulating factor-dependent myelobl...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Mol Cell Biol
Autori principali:	Lu, Q, Knoepfler, P S, Scheele, J, Wright, D D, Kamps, M P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230617/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7791786/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.7.3786
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!