E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.

The E2A-HLF fusion gene, formed by the t(17;19)(q22;p13) translocation in childhood acute pro-B-cell leukemia, encodes a hybrid protein that contains the paired trans-activation domains of E2A (E12/E47) linked to the basic region/leucine zipper DNA-binding and dimerization domain of hepatic leukemia...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Yoshihara, T, Inaba, T, Shapiro, L H, Kato, J Y, Look, A T
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230557/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7760820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.6.3247
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