The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.

The beta receptor for platelet-derived growth factor (beta PDGFR) is activated by binding of PDGF and undergoes phosphorylation at multiple tyrosine residues. The tyrosine-phosphorylated receptor associates with numerous SH2-domain-containing proteins which include phospholipase C-gamma 1 (PLC gamma...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Valius, M, Secrist, J P, Kazlauskas, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7760802/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.6.3058
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