Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

Following binding of platelet-derived growth factor (PDGF), the PDGF alpha receptor (alphaPDGFR) becomes tyrosine phosphorylated and associates with a number of signal transduction molecules, including phospholipase Cgamma-1 (PLCgamma-1), phosphatidylinositol 3-kinase (PI3K), the phosphotyrosine pho...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Bazenet, C E, Gelderloos, J A, Kazlauskas, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC231696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943348/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.16.12.6926
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