Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.

The SHC proteins have been implicated in insulin receptor (IR) signaling. In this study, we used the sensitive two-hybrid assay of protein-protein interaction to demonstrate that SHC interacts directly with the IR. The interaction is mediated by SHC amino acids 1 to 238 and is therefore independent...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Gustafson, T A, He, W, Craparo, A, Schaub, C D, O'Neill, T J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7537849/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.5.2500
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