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Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.

T beta R-II (transforming growth factor beta [TGF-beta] type II receptor) is a transmembrane serine/threonine kinase that acts as the primary TGF-beta receptor. Ligand binding to T beta R-II leads to the recruitment and phosphorylation of T beta R-I, a distantly related transmembrane kinase that act...

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Publicat a:Mol Cell Biol
Autors principals: Cárcamo, J, Zentella, A, Massagué, J
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1995
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230381/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862150/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1573
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