The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.

Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and 13 [t(2;13) (q35;q14)]. The genes on each chromosome involved in this translocation have been identified as the transcription factor-encoding genes PAX3 and FKHR. The NH2...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Fredericks, W J, Galili, N, Mukhopadhyay, S, Rovera, G, Bennicelli, J, Barr, F G, Rauscher, F J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862145/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1522
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!