The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.

Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and 13 [t(2;13) (q35;q14)]. The genes on each chromosome involved in this translocation have been identified as the transcription factor-encoding genes PAX3 and FKHR. The NH2...

Description complète

Détails bibliographiques

Publié dans:	Mol Cell Biol
Auteurs principaux:	Fredericks, W J, Galili, N, Mukhopadhyay, S, Rovera, G, Bennicelli, J, Barr, F G, Rauscher, F J
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862145/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1522
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!