Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product.

The Wilms' tumor suppressor gene, WT1, encodes a zinc finger polypeptide which plays a key role regulating cell growth and differentiation in the urogenital system. Using the whole-genome PCR approach, we searched murine genomic DNA for high-affinity WT1 binding sites and identified a 10-bp motif 5'...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Nakagama, H, Heinrich, G, Pelletier, J, Housman, D E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230373/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1489
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