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Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins.

We have identified a gene, SHR5, in a screen for extragenic suppressors of the hyperactive RAS2Val-19 mutation in the budding yeast Saccharomyces cerevisiae. SHR5 was cloned, sequenced, and found to encode a 23-kDa protein not significantly homologous to other proteins in the current data bases. Gen...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Jung, V, Chen, L, Hofmann, S L, Wigler, M, Powers, S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 1995
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230357/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7532279/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.15.3.1333
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