Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.

The template for synthesis of hepadnaviral RNAs is a covalently closed circular (ccc) DNA located in the nucleus of the infected hepatocyte. Hepatocytes are normally long-lived and nondividing, and antiviral therapies in chronically infected individuals face the problem of eliminating not only the r...

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Bibliografske podrobnosti
Main Authors: Moraleda, G, Saputelli, J, Aldrich, C E, Averett, D, Condreay, L, Mason, W S
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC230243/
https://ncbi.nlm.nih.gov/pubmed/9371599
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