Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus.

The template for synthesis of hepadnaviral RNAs is a covalently closed circular (ccc) DNA located in the nucleus of the infected hepatocyte. Hepatocytes are normally long-lived and nondividing, and antiviral therapies in chronically infected individuals face the problem of eliminating not only the r...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Moraleda, G, Saputelli, J, Aldrich, C E, Averett, D, Condreay, L, Mason, W S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230243/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371599/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.12.9392-9399.1997
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