Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

Vectors derived from adeno-associated virus (AAV) are promising for human gene therapy, including treatment for retinal blindness. One major limitation of AAVs as vectors is that AAV cargo capacity has been considered to be restricted to 4.7 kb. Here we demonstrate that vectors with an AAV5 capsid (...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Allocca, Mariacarmela, Doria, Monica, Petrillo, Marco, Colella, Pasqualina, Garcia-Hoyos, Maria, Gibbs, Daniel, Kim, So Ra, Maguire, Albert, Rex, Tonia S., Di Vicino, Umberto, Cutillo, Luisa, Sparrow, Janet R., Williams, David S., Bennett, Jean, Auricchio, Alberto
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Technical Advance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2298836/
https://ncbi.nlm.nih.gov/pubmed/18414684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34316
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares