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Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice
Vectors derived from adeno-associated virus (AAV) are promising for human gene therapy, including treatment for retinal blindness. One major limitation of AAVs as vectors is that AAV cargo capacity has been considered to be restricted to 4.7 kb. Here we demonstrate that vectors with an AAV5 capsid (...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Clinical Investigation
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2298836/ https://ncbi.nlm.nih.gov/pubmed/18414684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34316 |
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