Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

Vectors derived from adeno-associated virus (AAV) are promising for human gene therapy, including treatment for retinal blindness. One major limitation of AAVs as vectors is that AAV cargo capacity has been considered to be restricted to 4.7 kb. Here we demonstrate that vectors with an AAV5 capsid (...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Allocca, Mariacarmela, Doria, Monica, Petrillo, Marco, Colella, Pasqualina, Garcia-Hoyos, Maria, Gibbs, Daniel, Kim, So Ra, Maguire, Albert, Rex, Tonia S., Di Vicino, Umberto, Cutillo, Luisa, Sparrow, Janet R., Williams, David S., Bennett, Jean, Auricchio, Alberto
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2008
Ämnen:
Technical Advance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2298836/
https://ncbi.nlm.nih.gov/pubmed/18414684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34316
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk