Induction of Protective Immunity against Malaria by Priming-Boosting Immunization with Recombinant Cold-Adapted Influenza and Modified Vaccinia Ankara Viruses Expressing a CD8(+)-T-Cell Epitope Derived from the Circumsporozoite Protein of Plasmodium yoelii

We immunized mice with an attenuated (cold-adapted) influenza virus followed by an attenuated vaccinia virus (modified vaccinia virus Ankara), both expressing a CD8(+)-T-cell epitope derived from malaria sporozoites. This vaccination regimen elicited high levels of protection against malaria. This i...

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Detalhes bibliográficos
Main Authors: González-Aseguinolaza, Gloria, Nakaya, Yurie, Molano, Alberto, Dy, Edward, Esteban, Mariano, Rodríguez, Dolores, Rodríguez, Juan Ramón, Palese, Peter, García-Sastre, Adolfo, Nussenzweig, Ruth S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC229373/
https://ncbi.nlm.nih.gov/pubmed/14557672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11859-11866.2003
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