The Hepatitis B Virus Polymerase Mutation rtV173L Is Selected during Lamivudine Therapy and Enhances Viral Replication In Vitro

Therapy of chronic hepatitis B virus (HBV) infection with the polymerase inhibitor lamivudine frequently is associated with the emergence of viral resistance. Genotypic changes in the YMDD motif (reverse transcriptase [rt] mutations rtM204V/I) conferred resistance to lamivudine as well as reducing t...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Delaney, William E., Yang, Huiling, Westland, Christopher E., Das, Kalyan, Arnold, Eddy, Gibbs, Craig S., Miller, Michael D., Xiong, Shelly
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2003
Ämnen:
Vaccines and Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC229343/
https://ncbi.nlm.nih.gov/pubmed/14557667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11833-11841.2003
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk