Oligodendrocyte-Specific Expression of Human Immunodeficiency Virus Type 1 Nef in Transgenic Mice Leads to Vacuolar Myelopathy and Alters Oligodendrocyte Phenotype In Vitro

Vacuolar myelopathy (VM) is a frequent central nervous system complication of human immunodeficiency virus type 1 (HIV-1) infection. We report here that transgenic (Tg) mice expressing even low levels of Nef in oligodendrocytes under the regulation of the myelin basic protein (MBP) promoter (MBP/HIV...

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Detalhes bibliográficos
Main Authors: Radja, Fatiha, Kay, Denis G., Albrecht, Steffen, Jolicoeur, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC229323/
https://ncbi.nlm.nih.gov/pubmed/14557659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.21.11745-11753.2003
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