Oligodendrocyte-Specific Expression of Human Immunodeficiency Virus Type 1 Nef in Transgenic Mice Leads to Vacuolar Myelopathy and Alters Oligodendrocyte Phenotype In Vitro

Vacuolar myelopathy (VM) is a frequent central nervous system complication of human immunodeficiency virus type 1 (HIV-1) infection. We report here that transgenic (Tg) mice expressing even low levels of Nef in oligodendrocytes under the regulation of the myelin basic protein (MBP) promoter (MBP/HIV...

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Bibliographic Details

Published in:	J Virol
Main Authors:	Radja, Fatiha, Kay, Denis G., Albrecht, Steffen, Jolicoeur, Paul
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2003
Subjects:	Pathogenesis and Immunity
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC229323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14557659/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.21.11745-11753.2003
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