The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress

Human renal clear cell carcinoma (RCC) is frequently associated with loss of the von Hippel-Lindau (VHL) tumor suppressor (pVHL), which inhibits ubiquitylation and degradation of the alpha subunits of hypoxia-inducible transcription factor. pVHL also ubiquitylates the large subunit of RNA polymerase...

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Autori principali: Mikhaylova, Olga, Ignacak, Monika L., Barankiewicz, Teresa J., Harbaugh, Svetlana V., Yi, Ying, Maxwell, Patrick H., Schneider, Martin, Van Geyte, Katie, Carmeliet, Peter, Revelo, Monica P., Wyder, Michael, Greis, Kenneth D., Meller, Jarek, Czyzyk-Krzeska, Maria F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293119/
https://ncbi.nlm.nih.gov/pubmed/18285459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01231-07
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