Activation of FoxM1 during G(2) Requires Cyclin A/Cdk-Dependent Relief of Autorepression by the FoxM1 N-Terminal Domain

The Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G(2) phase. Here, we show that FoxM1 transcriptional activity is kept low during G(1)/S through the action of its N-terminal autoinhibitory domain. We found that cyclin A/cdk complexes are required to pho...

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Detalhes bibliográficos
Main Authors: Laoukili, Jamila, Alvarez, Monica, Meijer, Lars A. T., Stahl, Marie, Mohammed, Shabaz, Kleij, Livio, Heck, Albert J. R., Medema, René H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293089/
https://ncbi.nlm.nih.gov/pubmed/18285455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01710-07
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