Kaposi's Sarcoma-Associated Herpesvirus Latent Gene vFLIP Inhibits Viral Lytic Replication through NF-κB-Mediated Suppression of the AP-1 Pathway: a Novel Mechanism of Virus Control of Latency

Kaposi's sarcoma-associated herpesvirus (KSHV) latency is central to the evasion of host immune surveillances and induction of KSHV-related malignancies. The mechanism of KSHV latency remains unclear. Here, we show that the KSHV latent gene vFLIP promotes viral latency by inhibiting viral lytic...

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Autores principales: Ye, Feng-Chun, Zhou, Fu-Chun, Xie, Jian-Ping, Kang, Tao, Greene, Whitney, Kuhne, Kurt, Lei, Xiu-Fen, Li, Qui-Hua, Gao, Shou-Jiang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293065/
https://ncbi.nlm.nih.gov/pubmed/18305042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02370-07
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