Identification of an HLA-A*0201-Restricted T-Cell Epitope on the MPT51 Protein, a Major Secreted Protein Derived from Mycobacterium tuberculosis, by MPT51 Overlapping Peptide Screening

CD8(+) T cells play a pivotal role in protection against Mycobacterium tuberculosis infection. We identified a novel HLA-A*0201-restricted CD8(+) T-cell epitope on a dominant secreted antigen of M. tuberculosis, MPT51, in HLA-A*0201 transgenic HHD mice. HHD mice were immunized with plasmid DNA encod...

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Detalhes bibliográficos
Main Authors: Aoshi, Taiki, Nagata, Toshi, Suzuki, Mina, Uchijima, Masato, Hashimoto, Dai, Rafiei, Alireza, Suda, Takafumi, Chida, Kingo, Koide, Yukio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292891/
https://ncbi.nlm.nih.gov/pubmed/18212086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01381-07
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