Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

Pneumolysin is a pore-forming cytolysin known as a major virulence determinant of Streptococcus pneumoniae. This protein toxin has also been shown to activate the Toll-like receptor 4 (TLR4) signaling pathway. In this study, a mutant S. pneumoniae strain deficient in pneumolysin (Δply) and a recombi...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Shoma, Shereen, Tsuchiya, Kohsuke, Kawamura, Ikuo, Nomura, Takamasa, Hara, Hideki, Uchiyama, Ryosuke, Daim, Sylvia, Mitsuyama, Masao
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology (ASM) 2008
الموضوعات:
Host Response and Inflammation
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292879/
https://ncbi.nlm.nih.gov/pubmed/18195026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01269-07
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