In Vivo Response to Methotrexate Forecasts Outcome of Acute Lymphoblastic Leukemia and Has a Distinct Gene Expression Profile

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is the most common cancer in children, and can now be cured in approximately 80% of patients. Nevertheless, drug resistance is the major cause of treatment failure in children with ALL. The drug methotrexate (MTX), which is widely used to trea...

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Główni autorzy: Sorich, Michael J, Pottier, Nicolas, Pei, Deqing, Yang, Wenjian, Kager, Leo, Stocco, Gabriele, Cheng, Cheng, Panetta, John C, Pui, Ching-Hon, Relling, Mary V, Cheok, Meyling H, Evans, William E
Format: Artigo
Język:Inglês
Wydane: Public Library of Science 2008
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Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292747/
https://ncbi.nlm.nih.gov/pubmed/18416598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0050083
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