Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication

A novel small-molecule inhibitor, referred to here as R706, was discovered in a high-throughput screen of chemical libraries against Huh-7-derived replicon cells carrying autonomously replicating subgenomic RNA of hepatitis C virus (HCV). R706 was highly potent in blocking HCV RNA replication as mea...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Huang, Peiyong, Goff, Dane A., Huang, Qi, Martinez, Anthony, Xu, Xiang, Crowder, Scott, Issakani, Sarkiz D., Anderson, Emily, Sheng, Ning, Achacoso, Philip, Yen, Ann, Kinsella, Todd, Darwish, Ihab S., Kolluri, Rao, Hong, Hui, Qu, Kunbin, Stauffer, Emily, Goldstein, Eileen, Singh, Rajinder, Payan, Donald G., Lu, H. Henry
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292530/
https://ncbi.nlm.nih.gov/pubmed/18227176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00525-07
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky