Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication

A novel small-molecule inhibitor, referred to here as R706, was discovered in a high-throughput screen of chemical libraries against Huh-7-derived replicon cells carrying autonomously replicating subgenomic RNA of hepatitis C virus (HCV). R706 was highly potent in blocking HCV RNA replication as mea...

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מידע ביבליוגרפי
Main Authors: Huang, Peiyong, Goff, Dane A., Huang, Qi, Martinez, Anthony, Xu, Xiang, Crowder, Scott, Issakani, Sarkiz D., Anderson, Emily, Sheng, Ning, Achacoso, Philip, Yen, Ann, Kinsella, Todd, Darwish, Ihab S., Kolluri, Rao, Hong, Hui, Qu, Kunbin, Stauffer, Emily, Goldstein, Eileen, Singh, Rajinder, Payan, Donald G., Lu, H. Henry
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2008
נושאים:
Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292530/
https://ncbi.nlm.nih.gov/pubmed/18227176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00525-07
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