Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication

A novel small-molecule inhibitor, referred to here as R706, was discovered in a high-throughput screen of chemical libraries against Huh-7-derived replicon cells carrying autonomously replicating subgenomic RNA of hepatitis C virus (HCV). R706 was highly potent in blocking HCV RNA replication as mea...

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Detalhes bibliográficos
Main Authors: Huang, Peiyong, Goff, Dane A., Huang, Qi, Martinez, Anthony, Xu, Xiang, Crowder, Scott, Issakani, Sarkiz D., Anderson, Emily, Sheng, Ning, Achacoso, Philip, Yen, Ann, Kinsella, Todd, Darwish, Ihab S., Kolluri, Rao, Hong, Hui, Qu, Kunbin, Stauffer, Emily, Goldstein, Eileen, Singh, Rajinder, Payan, Donald G., Lu, H. Henry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292530/
https://ncbi.nlm.nih.gov/pubmed/18227176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00525-07
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