Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent

Debio-025 is a synthetic cyclosporine with no immunosuppressive capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity. A lack of immunosuppressive effects compared to that of cyclosporine was demonstrated both in vitro and in vivo...

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Hlavní autoři: Ptak, Roger G., Gallay, Philippe A., Jochmans, Dirk, Halestrap, Andrew P., Ruegg, Urs T., Pallansch, Luke A., Bobardt, Michael D., de Béthune, Marie-Pierre, Neyts, Johan, De Clercq, Erik, Dumont, Jean-Maurice, Scalfaro, Pietro, Besseghir, Kamel, Wenger, Roland M., Rosenwirth, Brigitte
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292519/
https://ncbi.nlm.nih.gov/pubmed/18212100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01324-07
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