IL-13 induces a bronchial epithelial phenotype that is profibrotic

BACKGROUND: Inflammatory cytokines (e.g. IL-13) and mechanical perturbations (e.g. scrape injury) to the epithelium release profibrotic factors such as TGF-β(2), which may, in turn, stimulate subepithelial fibrosis in asthma. We hypothesized that prolonged IL-13 exposure creates a plastic epithelial...

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Main Authors: Malavia, Nikita K, Mih, Justin D, Raub, Christopher B, Dinh, Bao T, George, Steven C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292179/
https://ncbi.nlm.nih.gov/pubmed/18348727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-9-27
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