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Roles of Greatwall Kinase in the Regulation of Cdc25 Phosphatase

We previously reported that immunodepletion of Greatwall kinase prevents Xenopus egg extracts from entering or maintaining M phase due to the accumulation of inhibitory phosphorylations on Thr14 and Tyr15 of Cdc2. M phase–promoting factor (MPF) in turn activates Greatwall, implying that Greatwall pa...

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Autors principals: Zhao, Yong, Haccard, Olivier, Wang, Ruoning, Yu, Jiangtao, Kuang, Jian, Jessus, Catherine, Goldberg, Michael L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291418/
https://ncbi.nlm.nih.gov/pubmed/18199678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-11-1099
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